A number of large current experiments aim to detect the signatures of the Cosmic Reionization at redshifts z>6. Their success depends crucially on understanding the character of the reionization process and its observable consequences and designing the best strategies to use. We use large-scale simulations of cosmic reionization to evaluate the reionization signatures at redshifted 21-cm and small-scale CMB anisotropies in the best current model for the background universe, with fundamental cosmological parameters given by WMAP 3-year results (WMAP3). We find that the optimal frequency range for observing the ``global step of the 21-cm emission is 120-150 MHz, while statistical studies should aim at 140-160 MHz, observable by GMRT. Some strongly-nongaussian brightness features should be detectable at frequencies up to ~190 MHz. In terms of sensitivity-signal trade-off relatively low resolutions, corresponding to beams of at least a few arcminutes, are preferable. The CMB anisotropy signal from the kinetic Sunyaev-Zeldovich effect from reionized patches peaks at tens of muK at arcminute scales and has an rms of ~1 muK, and should be observable by the Atacama Cosmology Telescope and the South Pole Telescope. We discuss the various observational issues and the uncertainties involved, mostly related to the poorly-known reionization parameters and, to a lesser extend, to the uncertainties in the background cosmology.
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