GRB 050730 is a long duration high-redshift burst (z=3.967) discovered by Swift. The afterglow shows variability and is well monitored over a wide wavelength range. We present comprehensive temporal and spectral analysis of the afterglow of GRB 050730 including observations from the millimeter to X-rays. We use multi-wavelength afterglow data to understand the temporal and spectral decay properties with superimposed variability of this high redshift burst. Five telescopes were used to study the decaying afterglow of GRB 050730 in the B, V, r, R, i, I, J and K photometric pass bands. A spectral energy distribution was constructed at 2.9 hours post-burst in the K, J, I, R, V and B bands. X-ray data from the satellites Swift and XMM-Newton were used to study the afterglow evolution at higher energies. The early afterglow shows variability at early times and shows a steepening at ~0.1 days (8.6 ks) in the B, V, r, R, i, I, J and K passbands. The early afterglow light curve decayed with alpha_1 = -0.60+/-0.07 and alpha_2 = -1.71+/-0.06 based on R and I band data. A millimeter detection of the afterglow around 3 days after the burst shows an excess in comparison to predictions. The early X-ray light curve observed by Swift is complex and contains flares. At late times the X-ray light curve can be fit by a powerlaw alpha_x = -2.5+/-0.15 which is steeper than the optical light curve. A spectral energy distribution (SED) was constructed at ~2.9 hours after the burst. An electron energy index, p, of ~ 2.3 was calculated using the SED and the photon index from the X-ray afterglow spectra and indicates that the synchrotron cooling frequency nu_c is above observed frequencies.