In this paper, we prove a combination theorem for indicable subgroups of infinite-type (or big) mapping class groups. Importantly, all subgroups from the combination theorem, as well as those from the other results of the paper, can be constructed so that they do not lie in the closure of the compactly supported mapping class group and do not lie in the isometry group for any hyperbolic metric on the relevant infinite-type surface. Along the way, we prove an embedding theorem for indicable subgroups of mapping class groups, a corollary of which gives embeddings of pure big mapping class groups into other big mapping class groups that are not induced by embeddings of the underlying surfaces. We also give new constructions of free groups, wreath products with $mathbb Z$, and Baumslag-Solitar groups in big mapping class groups that can be used as an input for the combination theorem. One application of our combination theorem is a new construction of right-angled Artin groups in big mapping class groups.