Acoustic impedance mismatches between soft tissues and bones are known to result in strong aberrations in optoacoustic and ultrasound images. Of particular importance are the severe distortions introduced by the human skull, impeding transcranial brain imaging with these modalities. While modelling of ultrasound propagation through the skull may in principle help correcting for some of the skull-induced aberrations, these approaches are commonly challenged by the highly heterogeneous and dispersive acoustic properties of the skull and lack of exact knowledge on its geometry and internal structure. Here we demonstrate that the spatio-temporal properties of the acoustic distortions induced by the skull are preserved for signal sources generated at neighboring intracranial locations by means of optoacoustic excitation. This optoacoustic memory effect is exploited for building a three-dimensional model accurately describing the generation, propagation and detection of time-resolved broadband optoacoustic waveforms traversing the skull. The memory-based model-based inversion is then shown to accurately recover the optical absorption distribution inside the skull with spatial resolution and image quality comparable to those attained in skull-free medium.
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