Hybrid quantum systems aim at combining the advantages of different physical systems and to produce novel quantum devices. In particular, the hybrid combination of superconducting circuits and spins in solid-state crystals is a versatile platform to explore many quantum electrodynamics problems. Recently, the remote coupling of nitrogen-vacancy center spins in diamond via a superconducting bus was demonstrated. However, a rigorous experimental test of the quantum nature of this hybrid system and in particular entanglement is still missing. We review the theoretical ideas to generate and detect entanglement, and present our own scheme to achieve this.