Within the framework of Galileon inflation with quartic and natural potentials, we investigate generation of the primordial black holes (PBHs) and induced gravitational waves (GWs). In this setup, we consider a Galileon function as $G(phi)=g_I(phi)big(1+g_{II}(phi)big)$ and show that in the presence of first term $g_I(phi)$ both quartic and natural potentials, in contrast to the standard model of inflation, can be consistent, with the 68% CL of Planck observations. Besides, the second term $g_{II}(phi)$ can cause a significant enhancement in the primordial curvature perturbations at the small scales which results the PBHs formation. For the both potentials, we obtain an enhancement in the scalar power spectrum at the scales $ksim10^{12}~rm Mpc^{-1}$, $10^{8}~rm Mpc^{-1}$, and $10^{5}~rm Mpc^{-1}$, which causes PBHs production in mass scales around $10^{-13}M_{odot}$, $10^{-5}M_{odot}$, and $10 M_{odot}$, respectively. Observational constraints confirm that PBHs with a mass scale of $10^{-13}M_{odot}$ can constitute the total of dark matter in the universe. Furthermore, we estimate the energy density parameter of induced GWs which can be examined by the observation. Also we conclude that it can be parametrized as a power-law function $Omega_{rm GW}sim (f/f_c)^n$, where the power index equals $n=3-2/ln(f_c/f)$ in the infrared limit $fll f_{c}$.