The results of speckle interferometric observations at the 4.1 m Southern Astrophysical Research Telescope (SOAR) in 2020, as well as earlier unpublished data, are given, totaling 1735 measurements of 1288 resolved pairs and non-resolutions of 1177 targets. We resolved for the first time 59 new pairs or subsystems in known binaries, mostly among nearby dwarf stars. This work continues our long-term speckle program. Its main goal is to monitor orbital motion of close binaries, including members of high-order hierarchies and Hipparcos pairs in the solar neighborhood. We also report observations of 892 members of young moving groups and associations, where we resolved 103 new pairs.