Classical scale invariance (CSI) is an attractive concept for BSM model building, explaining the apparent alignment of the Higgs sector and potentially relating to the hierarchy problem. Furthermore, a particularly interesting feature is that the Higgs trilinear coupling $lambda_{hhh}$ is universally predicted at one loop in CSI models, and deviates by 67% from its (tree-level) SM prediction. This result is however modified at two loops, and we review in these proceedings our calculation of leading two-loop corrections to $lambda_{hhh}$ in models with classical scale invariance, taking as an example a CSI scenario of a Two-Higgs-Doublet Model. We find that the inclusion of two-loop effects allows distinguishing different scenarios with CSI, although the requirement of reproducing the known 125-GeV Higgs-boson mass severely restricts the allowed values of $lambda_{hhh}$.