The [O III ] 5007 Planetary Nebula Luminosity Function (PNLF) is an established distance indicator that has been used for more than 30 years to measure the distances of galaxies out to ~15 Mpc. With the advent of the Multi-Unit Spectroscopic Explorer on the Very Large Telescope (MUSE) as an efficient wide-field integral field spectrograph, the PNLF method is due for a renaissance, as the spatial and spectral information contained in the instruments datacubes provides many advantages over classical narrow-band imaging. Here we use archival MUSE data to explore the potential of a novel differential emission-line filter (DELF) technique to produce spectrophotometry that is more accurate and more sensitive than other methods. We show that DELF analyses are superior to classical techniques in high surface brightness regions of galaxies and we validate the method both through simulations and via the analysis of data from two early-type galaxies (NGC 1380 and NGC 474) and one late-type spiral (NGC 628). We demonstrate that with adaptive optics support or under excellent seeing conditions, the technique is capable of producing precision (< 0.05 mag) [O III ] photometry out to distances of 40 Mpc while providing discrimination between planetary nebulae and other emission-line objects such as H II regions, supernova remnants, and background galaxies. These capabilities enable us to use MUSE to measure precise PNLF distances beyond the reach of Cepheids and the tip of the red giant branch method, and become an additional tool for constraining the local value of the Hubble constant.
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