We study high-dimensional Bayesian linear regression with product priors. Using the nascent theory of non-linear large deviations (Chatterjee and Dembo,2016), we derive sufficient conditions for the leading-order correctness of the naive mean-field approximation to the log-normalizing constant of the posterior distribution. Subsequently, assuming a true linear model for the observed data, we derive a limiting infinite dimensional variational formula for the log normalizing constant of the posterior. Furthermore, we establish that under an additional separation condition, the variational problem has a unique optimizer, and this optimizer governs the probabilistic properties of the posterior distribution. We provide intuitive sufficient conditions for the validity of this separation condition. Finally, we illustrate our results on concrete examples with specific design matrices.