Extraction of the multi-TeV proton and lead LHC beams with a bent crystal or by using an internal gas target allows one to perform the most energetic fixed-target experiment ever. pp, pd and pA collisions at $sqrt{s}$ = 115 GeV and Pbp and PbA collisions at $sqrt{s_{rm{NN}}}$ = 72 GeV can be studied with high precision and modern detection techniques over a broad rapidity range. Using the LHCb or the ALICE detector in a fixed-target mode offers unprecedented possibilities to access heavy-flavour production in a new energy domain, half way between the SPS and the nominal RHIC energy. In this contribution, a review of projection studies for quarkonium and open charm and beauty production with both detector set-ups used with various nuclear targets and the LHC lead beams is presented.
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