Significant deviations from the Standard Model are observed in semileptonic charged and neutral-current B-decays, the muon magnetic moment, and the extraction of the Cabibbo angle. We propose that these deviations point towards a coherent pattern of New Physics effects induced by two scalar mediators, a leptoquark $S_1$ and a charged singlet $phi^+$. While $S_1$ can provide solutions to charged-current $B$-decays and the muon magnetic moment, and $phi^+$ can accommodate the Cabibbo-angle anomaly independently, their one-loop level synergy can also address neutral-current $B$-decays. This framework provides the most minimal explanation to the above-mentioned anomalies, while being consistent with all other phenomenological constraints.
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