The Vlasov-Poisson-Boltzmann equation is a classical equation governing the dynamics of charged particles with the electric force being self-imposed. We consider the system in a convex domain with the Cercignani-Lampis boundary condition. We construct a uniqueness local-in-time solution based on an $L^infty$-estimate and $W^{1,p}$-estimate. In particular, we develop a new iteration scheme along the characteristic with the Cercignani-Lampis boundary for the $L^infty$-estimate, and an intrinsic decomposition of boundary integral for $W^{1,p}$-estimate.