In fully-developed pressure-driven flow, the spreading of a dissolved solute is enhanced in the flow direction due to transverse velocity variations in a phenomenon now commonly referred to as Taylor-Aris dispersion. It is well understood that the characteristics of the dispersion are sensitive to the channels cross-sectional geometry. Here we demonstrate a method for manipulation of dispersion in a single rectangular microchannel via controlled deformation of its upper wall. Using a rapidly prototyped multi-layer microchip, the channel wall is deformed by a controlled pressure source allowing us to characterize the dependence of the dispersion on the deflection of the channel wall and overall channel aspect ratio. For a given channel aspect ratio, an optimal deformation to minimize dispersion is found, consistent with prior numerical and theoretical predictions. Our experimental measurements are also compared directly to numerical predictions using an idealized geometry.
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