Outflows from active galactic nuclei (AGN) are one of the fundamental mechanisms by which the central supermassive black hole interacts with its host galaxy. Detected in $ge 50%$ of nearby AGN, these outflows have been found to carry kinetic energy that is a significant fraction of AGN power, and thereby give negative feedback to their host galaxies. To understand the physical processes that regulate them, it is important to have a robust estimate of their physical and dynamical parameters. In this review we summarize our current understanding on the physics of the ionized outflows detected in absorption in the UV and X-ray wavelength bands. We discuss the most relevant observations and our current knowledge and uncertainties in the measurements of the outflow parameters. We also discuss their origin and acceleration mechanisms. The commissioning and concept studies of large telescope missions with high resolution spectrographs in UV/optical and X-rays along with rapid advancements in simulations offer great promise for discoveries in this field over the next decade.
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