We present a novel diffractive imaging method that harnesses a low-resolution real-space image to guide the phase retrieval. A computational algorithm is developed to utilize such prior knowledge as a real-space constraint in the iterative phase retrieval procedure. Numerical simulations and proof-of-concept experiments are carried out, demonstrating our methods capability of reconstructing high-resolution details that are otherwise inaccessible with traditional phasing algorithms. With the present method, we formulate a conceptual design for the coherent imaging experiments at a next-generation X-ray light source.
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