Critical aspects of computational imaging systems, such as experimental design and image priors, can be optimized through deep networks formed by the unrolled iterations of classical model-based reconstructions (termed physics-based networks). However, for real-world large-scale inverse problems, computing gradients via backpropagation is infeasible due to memory limitations of graphics processing units. In this work, we propose a memory-efficient learning procedure that exploits the reversibility of the networks layers to enable data-driven design for large-scale computational imaging systems. We demonstrate our method on a small-scale compressed sensing example, as well as two large-scale real-world systems: multi-channel magnetic resonance imaging and super-resolution optical microscopy.
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