We present a non-trivial integration of dimension-independent likelihood-informed (DILI) MCMC (Cui, Law, Marzouk, 2016) and the multilevel MCMC (Dodwell et al., 2015) to explore the hierarchy of posterior distributions. This integration offers several advantages: First, DILI-MCMC employs an intrinsic likelihood-informed subspace (LIS) (Cui et al., 2014) -- which involves a number of forward and adjoint model simulations -- to design accelerated operator-weighted proposals. By exploiting the multilevel structure of the discretised parameters and discretised forward models, we design a Rayleigh-Ritz procedure to significantly reduce the computational effort in building the LIS and operating with DILI proposals. Second, the resulting DILI-MCMC can drastically improve the sampling efficiency of MCMC at each level, and hence reduce the integration error of the multilevel algorithm for fixed CPU time. To be able to fully exploit the power of multilevel MCMC and to reduce the dependencies of samples on different levels for a parallel implementation, we also suggest a new pooling strategy for allocating computational resources across different levels and constructing Markov chains at higher levels conditioned on those simulated on lower levels. Numerical results confirm the improved computational efficiency of the multilevel DILI approach.
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