Most semantic segmentation models treat semantic segmentation as a pixel-wise classification task and use a pixel-wise classification error as their optimization criterions. However, the pixel-wise error ignores the strong dependencies among the pixels in an image, which limits the performance of the model. Several ways to incorporate the structure information of the objects have been investigated, eg, conditional random fields (CRF), image structure priors based methods, and generative adversarial network (GAN). Nevertheless, these methods usually require extra model branches or additional memories, and some of them show limited improvements. In contrast, we propose a simple yet effective structural similarity loss (SSL) to encode the structure information of the objects, which only requires a few additional computational resources in the training phase. Inspired by the widely-used structural similarity (SSIM) index in image quality assessment, we use the linear correlation between two images to quantify their structural similarity. And the goal of the proposed SSL is to pay more attention to the positions, whose associated predictions lead to a low degree of linear correlation between two corresponding regions in the ground truth map and the predicted map. Thus the model can achieve a strong structural similarity between the two maps through minimizing the SSL over the whole map. The experimental results demonstrate that our method can achieve substantial and consistent improvements in performance on the PASCAL VOC 2012 and Cityscapes datasets. The code will be released soon.