The connection between the dipolar modulation asymmetry and the quadrupole-octopole alignment in the CMB is studied in this work. First, a generalization of the dipolar modulation model is proposed by considering that the amplitude may depend on the scale. As derived from a Bayesian inference analysis, this model fits the CMB data better than the scale-independent one. As an extension of the standard model, the scale-dependent dipolar modulation shows comparable evidence to the standard isotropic model in the large scales ($ell_mathrm{max} leq 64$). The posterior distribution of the parameters of the scale-dependent model suggests that the amplitude of the dipolar modulation is large at the lowest multipoles. This large asymmetry induces a detectable correlation between the quadrupole and the octopole. The significance of the quadrupole-octopole alignment is analyzed under the assumption that the Universe has a scale-dependent dipolar modulation. The three alignment estimators considered in this paper show an increment of $80%$ in the p-value, showing a clear correlation between these two CMB anomalies. Within this new scenario, only one of the alignment estimators is still below the $1%$ probability level.
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