The self-energy effect on the neutron-proton (np) pairing gap is investigated up to the third order within the framework of the extend Bruecker-Hartree-Fock (BHF) approach combined with the BCS theory. The self-energy up to the second-order contribution turns out to reduce strongly the effective energy gap, while the emph{renormalization} term enhances it significantly. In addition, the effect of the three-body force on the np pairing gap is shown to be negligible. To connect the present results with the np pairing in finite nuclei, an effective density-dependent zero-range pairing force is established with the parameters calibrated to the microscopically calculated energy gap.
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