We consider derived invariants of varieties in positive characteristic arising from topological Hochschild homology. Using theory developed by Ekedahl and Illusie-Raynaud in their study of the slope spectral sequence, we examine the behavior under derived equivalences of various $p$-adic quantities related to Hodge-Witt and crystalline cohomology groups, including slope numbers, domino numbers, and Hodge-Witt numbers. As a consequence, we obtain restrictions on the Hodge numbers of derived equivalent varieties, partially extending results of Popa-Schell to positive characteristic.
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