The ACME collaboration has recently announced a new constraint on the electron EDM, $|d_e| < 1.1 times 10^{-29}, e, {rm cm}$, from measurements of the ThO molecule. This is a powerful constraint on CP-violating new physics: even new physics generating the EDM at two loops is constrained at the multi-TeV scale. We interpret the bound in the context of different scenarios for new physics: a general order-of-magnitude analysis for both the electron EDM and the CP-odd electron-nucleon coupling; 1-loop SUSY, probing sleptons above 10 TeV; 2-loop SUSY, probing multi-TeV charginos or stops; and finally, new physics that generates the EDM via the charm quark or top quark Yukawa couplings. In the last scenario, new physics generates a QULE operator $(q_f bar{sigma}^{mu u}{bar u}_f) cdot (ell {bar{sigma}}_{mu u} {bar e})$, which in turn generates the EDM through RG evolution. If the QULE operator is generated at tree level, this corresponds to a previously studied leptoquark model. For the first time, we also classify scenarios in which the QULE operator is generated at one loop through a box diagram, which include SUSY and leptoquark models. The electron EDM bound is the leading constraint on a wide variety of theories of CP-violating new physics interacting with the Higgs boson or the top quark. We argue that any future nonzero measurement of an electron EDM will provide a strong motivation for constructing new colliders at the highest feasible energies.
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