We review progress in the study of antinuclei, starting from Diracs equation and the discovery of the positron in cosmic-ray events. The development of proton accelerators led to the discovery of antiprotons, followed by the first antideuterons, demonstrating that antinucleons bind into antinuclei. With the development of heavy-ion programs at the Brookhaven AGS and CERN SPS, it was demonstrated that central collisions of heavy nuclei offer a fertile ground for research and discoveries in the area of antinuclei. In this review, we emphasize recent observations at Brookhavens Relativistic Heavy Ion Collider and at CERNs Large Hadron Collider, namely, the antihypertriton and the antihelium-4, as well as measurements of the mass difference between light nuclei and antinuclei, and the interaction between antiprotons. Physics implications of the new observations and different production mechanisms are discussed. We also consider implications for related fields, such as hypernuclear physics and space-based cosmic-ray experiments.
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