Brane supersymmetry breaking is a peculiar phenomenon that can occur in perturbative orientifold vacua. It results from the simultaneous presence, in the vacuum, of non-mutually BPS sets of BPS branes and orientifolds, which leave behind a net tension and thus a runaway potential, but no tachyons. In the simplest ten-dimensional realization, the low-lying modes combine the closed sector of type-I supergravity with an open sector including USp(32) gauge bosons, fermions in the antisymmetric 495 and an additional singlet playing the role of a goldstino. We review some properties of this system and of other non-tachyonic models in ten dimensions with broken supersymmetry, and we illustrate some puzzles that their very existence raises, together with some applications that they have stimulated.
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