We present a fully many-body formulation of topological invariants for various topological phases of fermions protected by antiunitary symmetry, which does not refer to single particle wave functions. For example, we construct the many-body $mathbb{Z}_2$ topological invariant for time-reversal symmetric topological insulators in two spatial dimensions, which is a many-body counterpart of the Kane-Mele $mathbb{Z}_2$ invariant written in terms of single-particle Bloch wave functions. We show that an important ingredient for the construction of the many-body topological invariants is a fermionic partial transpose which is basically the standard partial transpose equipped with a sign structure to account for anti-commuting property of fermion operators. We also report some basic results on various kinds of pin structures -- a key concept behind our strategy for constructing many-body topological invariants -- such as the obstructions, isomorphism classes, and Dirac quantization conditions.
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