New models of the SU(2|1) supersymmetric mechanics based on gauging the systems with dynamical (1,4,3) and semi-dynamical (4,4,0) supermultiplets are presented. We propose a new version of SU(2|1) harmonic superspace approach which makes it possible to construct the Wess-Zumino term for interacting (4,4,0) multiplets. A new N=4 extension of d=1 Calogero-Moser multiparticle system is obtained by gauging the U(n) isometry of matrix SU(2|1) harmonic superfield model.
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