We investigate the set of excluded minors of connectivity 2 for the class of frame matroids. We exhibit a list $mathcal{E}$ of 18 such matroids, and show that if $N$ is such an excluded minor, then either $N in mathcal{E}$ or $N$ is a 2-sum of $U_{2,4}$ and a 3-connected non-binary frame matroid.