We investigate the signatures at the Large Hadron Collider of a minimal model where the dark matter particle is a Majorana fermion that couples to the Standard Model via one or several coloured mediators. We emphasize the importance of the production channel of coloured scalars through the exchange of a dark matter particle in the t-channel, and perform a dedicated analysis of searches for jets and missing energy for this model. We find that the collider constraints are highly competitive compared to direct detection, and can even be considerably stronger over a wide range of parameters. We also discuss the complementarity with searches for spectral features at gamma-ray telescopes and comment on the possibility of several coloured mediators, which is further constrained by flavour observables.