Let $n$ be a positive integer and $f(x)$ be a polynomial with nonnegative integer coefficients. We prove that ${rm lcm}_{lceil n/2rceil le ile n} {f(i)}ge 2^n$ except that $f(x)=x$ and $n=1, 2, 3, 4, 6$ and that $f(x)=x^s$ with $sge 2$ being an integer and $n=1$, where $lceil n/2rceil$ denotes the smallest integer which is not less than $n/2$. This improves and extends the lower bounds obtained by Nair in 1982, Farhi in 2007 and Oon in 2013.
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