We operate a superconducting quantum processor consisting of two tunable transmon qubits coupled by a swapping interaction, and equipped with non destructive single-shot readout of the two qubits. With this processor, we run the Grover search algorithm among four objects and find that the correct answer is retrieved after a single run with a success probability between 0.52 and 0.67, significantly larger than the 0.25 achieved with a classical algorithm. This constitutes a proof-of-concept for the quantum speed-up of electrical quantum processors.