This lecture reviews the fundamental physical processes involved in star formation in galaxy interactions and mergers. Interactions and mergers often drive intense starbursts, but the link between interstellar gas physics, large scale interactions, and active star formation is complex and not fully understood yet. Two processes can drive starbursts: radial inflows of gas can fuel nuclear starbursts, triggered gas turbulence and fragmentation can drive more extended starbursts in massive star clusters with high fractions of dense gas. Both modes are certainly required to account for the observed properties of starbursting mergers. A particular consequence is that star formation scaling laws are not universal, but vary from quiescent disks to starbursting mergers. High-resolution hydrodynamic simulations are used to illustrate the lectures.