The Higgs boson decay into a pair of real or virtual W bosons, with one of them decaying leptonically, is predicted within the Standard Model to have the largest branching fraction of all Higgs decays that involve an isolated electron or muon, for M_h > 120 GeV. We compute analytically the fully-differential width for this h -> l u jj decay at tree level, and then explore some multi-dimensional cuts that preserve the region of large signal. Future searches for semileptonic decays at the Tevatron and LHC, employing fully-differential information as outlined here, may be essential for ruling out or in the Higgs boson and for characterizing a Higgs signal.
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