Two quantum Macro-states and their Macroscopic Quantum Superpositions (MQS) localized in two far apart, space - like separated sites can be non-locally correlated by any entangled couple of single-particles having interacted in the past. This novel Macro - Macro paradigm is investigated on the basis of a recent study on an entangled Micro-Macro system involving N=10^5 particles. Crucial experimental issues as the violation of Bells inequalities by the Macro - Macro system are considered.