The data on investigation of inelastic interactions of $16^O$ nuclei with a proton at 3.25 A GeV/c momentum by the bubble chamber method are presented. The separate characteristics as fragments isotopic composition and as topo-logical cross sections of fragmentation channels are given. The processes of light fragments formation and breakup of $16^O$ nucleus on multicharge fragments have been investigated. The comparison of experimental data with the calculations by statistical multifragmentation model was conducted.
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