The Superkamiokande experiment suggests the large flavor mixing between nu_mu and nu_tau. We show that the mixing angle receives significant corrections from the renormalization group equation (RGE) when both the second and the third generation neutrino masses are larger than O(0.1eV). This means that the mixing angle must be small at the decoupling scale of right-handed neutrinos in the model containing a sterile neutrino nu_s with the mass spectrum of m_nu_s = m_nu_e << m_nu_mu = m_nu_tau.