We study the effect from a sequential fourth generation quark on penguin-dominated two-body nonleptonic B meson decays in the next-to-leading order perturbative QCD formalism. With an enhancement of the color-suppressed tree amplitude and possibility of a new CP phase in the electroweak penguin, we can account better for A_{CP}(B^0 -> K^+ pi^-)-A_{CP}(B^+ -> K^+ pi^0). Taking |V_{ts}V_{tb}| sim 0.02 with phase just below 90^circ, which are consistent with the b -> s l^+ l^- rate and the B_s mixing parameter Delta m_{B_s}, we find a downward shift in the mixing-induced CP asymmetries of B^0 -> K_S pi^0 and phi K_S. The predicted behavior for B^0 -> rho^0 K_S is opposite.
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