We present the CTEQ6HQ parton distribution set which is determined in the general variable flavor number scheme which incorporates heavy flavor mass effects; hence, this set provides advantages for precision observables which are sensitive to charm and bottom quark masses. We describe the analysis procedure, examine the predominant features of the new distributions, and compare with previous distributions. We also examine the uncertainties of the strange quark distribution and how the the recent NuTeV dimuon data constrains this quantity.