This paper addresses the question how to implement a desired two-qubit gate U using a given tunable two-qubit entangling interaction H_int. We present a general method which is based on the K_1 A K_2 decomposition of unitary matrices in SU(4) to calculate analytically the smallest number of two-qubit gates U_int [based on H_int] and single-qubit rotations, and the explicit sequence of these operations that are required to implement U. We illustrate our protocol by calculating the implementation of (1) the transformation from standard basis to Bell basis, (2) the CNOT gate, and (3) the quantum Fourier transform for two kinds of interaction - Heisenberg exchange interaction and quantum inductive coupling - and discuss the relevance of our results for solid-state qubits.
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