This manuscript reviews recent progress in our understanding of the nucleosynthesis of medium and heavy elements in supernovae. Recent hydrodynamical models of core-collapse supernovae show that a large amount of proton rich matter is ejected under strong neutrino fluxes. This matter constitutes the site of the vp-process where antineutrino absorption reactions catalyze the nucleosynthesis of nuclei with A > 64. Supernovae are also associated with the r-process responsible for the synthesis of the heaviest elements in nature. Fission during the r-process can play a major role in determining the final abundance patter and in explaining the almost universal features seen in metal-poor r-process-rich stars.
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