In this paper we analyze the evolution of actively star forming galaxies in the mid-infrared (MIR). This spectral region, characterized by continuum emission by hot dust and by the presence of strong emission features generally ascribed to polycyclic aromatic hydrocarbon (PAH) molecules, is the most strongly affected by the heating processes associated with star formation and/or active galactic nuclei (AGN). Following the detailed observational characterization of galaxies in the MIR by ISO, we have updated the modelling of this spectral region in our spectro-photometric model GRASIL (Silva et al. 1998). In the diffuse component we have updated the treatment of PAHs according to the model by Li & Draine (2001). As for the dense phase of the ISM associated with the star forming regions, the molecular clouds, we strongly decrease the abundance of PAHs as compared to that in the cirrus, basing on the observational evidences of the lack or weakness of PAH bands close to the newly formed stars, possibly due to the destruction of the molecules in strong UV fields. The robustness of the model is checked by fitting near infrared to radio broad band spectra and the corresponding detailed MIR spectra of a large sample of galaxies (Lu et al. 2003), at once. With this model, we have analyzed the larger sample of actively star forming galaxies by Dale et al. (2000). We show that the observed trends of galaxies in the ISO-IRAS-Radio color-color plots can be interpreted in terms of different evolutionary phases of star formation activity, and the consequent different dominance in the spectral energy distribution (SED) of the diffuse or dense phase of the ISM.
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