The INTEGRAL satellite was launched on October 17, 2002. All on-board instruments are operating successfully. In this paper, we focus on radiation effects on the Cadmium Telluride camera ISGRI. The spectral response of the camera is affected by cosmic particles depositing huge amount of energy, greater than the high threshold of the electronics. Our study raises the contribution of cosmic ray protons. Solutions are proposed to limit the degradation of spectral response of large pixel gamma cameras operating in space.
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