(Abridged) We have obtained HST WFPC2 observations of three very luminous but morphologically different giant HII regions (GHRs) in M101, NGC5461, NGC5462, and NGC5471, in order to study cluster formation in GHRs. The measured (M_F547M - M_F675W) colors and M_F547M magnitudes are used to determine the ages and masses of the cluster candidates with M_F547M <= -9.0. NGC5461 is dominated by a very luminous core, and has been suggested to host a super-star cluster (SSC). Our observations show that it contains three R136-class clusters superposed on a bright stellar background in a small region. This tight group of clusters may dynamically evolve into an SSC in the future, and may appear unresolved and be identified as an SSC at large distances, but at present NGC5461 has no SSCs. NGC5462 has loosely distributed HII regions and clusters without a prominent core. It has the largest number of cluster candidates among the three GHRs, but most of them are faint and older than 10 Myr. NGC5471 has multiple bright HII regions, and contains a large number of faint clusters younger than 5 Myr. Two of the clusters in NGC5471 are older than R136, but just as luminous; they may be the most massive clusters in the three GHRs. The fraction of stars formed in massive clusters is estimated from the clusters contribution to the total stellar continuum emission and a comparison of the ionizing power of the clusters to the ionizing requirement of the associated HII regions. Both estimates show that <~ 50% of massive stars are formed in massive clusters. The cluster luminosity functions (CLFs) of the three GHRs show different slopes. NGC5462 has the steepest CLF and the most loosely distributed interstellar gas, qualitatively consistent with the hypothesis that massive clusters are formed in high-pressure interstellar environments.
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