In this contribution we present a few selected examples of how the latest generation of space-based instrumentation -- NASAs Chandra X-ray Observatory and the Far-Ultraviolet Spectroscopic Explorer (FUSE) -- are finally answering old questions about the influence of massive star feedback on the warm and hot phases of the ISM and IGM. In particular, we discuss the physical origin of the soft thermal X-ray emission in the halos of star-forming and starburst galaxies, its relationship to extra-planar H-alpha emission, and plasma diagnostics using FUSE observations of O VI absorption and emission.
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