Passive filtering is a common strategy used to reduce airborne disease transmission and particulate contaminants in buildings and individual covers. The engineering of high-performance filters with relatively low flow resistance but high virus- or particle-blocking efficiency is a nontrivial problem of paramount relevance, as evidenced in the variety of industrial filtration systems and the worldwide use of face masks. In this case, standard N95-level covers have high virus-blocking efficiency, but they can cause breathing discomfort. Next-generation industrial filters and masks should retain sufficiently small droplets and aerosols while having low resistance. We introduce a novel 3D printable particle filter inspired by animals complex nasal anatomy. Unlike standard random-media-based filters, the proposed concept relies on equally spaced channels with tortuous airflow paths. These two strategies induce distinct effects: a reduced resistance and a high likelihood of particle trapping by altering their trajectories with tortuous paths and induced local flow instability. The structures are tested for pressure drop and particle filtering efficiency over a wide range of airflow rates. We have also cross-validated the observed efficiency through numerical simulations. The designed filters exhibit a lower pressure drop than the commercial mask and air filters (N95, surgical, and high-efficiency particulate air (HEPA)). The concept provides a new approach to developing scalable, flexible, high-efficiency air filters for various engineering applications.