Rotating black holes without equatorial reflection symmetry can naturally arise in effective low-energy theories of fundamental quantum gravity, in particular, when parity-violating interactions are introduced. Adopting a theory-agnostic approach and considering a recently proposed Kerr-like black hole model, we investigate the structure and properties of accretion disk around a rotating black hole without reflection symmetry. In the absence of reflection symmetry, the accretion disk is in general a curved surface in shape, rather than a flat disk lying on the equatorial plane. Furthermore, the parameter $epsilon$ that controls the reflection asymmetry would shrink the size of the innermost stable circular orbits, and enhance the efficiency of the black hole in converting rest-mass energy to radiation during accretion. In addition, we find that spin measurements based on the gravitational redshift observations of the disk, assuming a Kerr geometry, may overestimate the true spin values if the central object is actually a Kerr-like black hole with conspicuous equatorial reflection asymmetry.