We revisit the following nonlinear critical elliptic equation begin{equation*} -Delta u+Q(y)u=u^{frac{N+2}{N-2}},;;; u>0;;;hbox{ in } mathbb{R}^N, end{equation*} where $Ngeq 5.$ Although there are some existence results of bubbling solutions for problem above, there are no results about the periodicity of bubbling solutions. Here we investigate some related problems. Assuming that $Q(y)$ is periodic in $y_1$ with period 1 and has a local minimum at 0 satisfying $Q(0)=0,$ we prove the existence and local uniqueness of infinitely many bubbling solutions of the problem above. This local uniqueness result implies that some bubbling solutions preserve the symmetry of the potential function $Q(y),$ i.e. the bubbling solution whose blow-up set is ${(jL,0,...,0):j=0,1,2,...,m}$ must be periodic in $y_{1}$ provided that $L$ is large enough, where $m$ is the number of the bubbles which is large enough but independent of $L.$ Moreover, we also show a non-existence of this bubbling solutions for the problem above if the local minimum of $Q(y)$ does not equal to zero.
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