Building on the well-known total-variation (TV), this paper develops a general regularization technique based on nonlinear isotropic diffusion (NID) for inverse problems with piecewise smooth solutions. The novelty of our approach is to be adaptive (we speak of A-NID) i.e. the regularization varies during the iterates in order to incorporate prior information on the edges, deal with the evolution of the reconstruction and circumvent the limitations due to the non-convexity of the proposed functionals. After a detailed analysis of the convergence and well-posedness of the method, this latter is validated by simulations perfomed on computerized tomography (CT).