Let $R$ be a commutative ring with identity and $S$ a multiplicative subset of $R$. In this paper, we introduce and study the notions of $S$-pure $S$-exact sequences and $S$-absolutely pure modules which extend the classical notions of pure exact sequences and absolutely pure modules. And then we characterize $S$-von Neumann regular rings and uniformly $S$-Noetherian rings using $S$-absolutely pure modules.