Multi-image super-resolution (MISR) usually outperforms single-image super-resolution (SISR) under a proper inter-image alignment by explicitly exploiting the inter-image correlation. However, the large computational demand encumbers the deployment of MISR methods in practice. In this work, we propose a distributed optimization framework based on data parallelism for fast large-scale MISR which supports multi- GPU acceleration, named FL-MISR. Inter-GPU communication for the exchange of local variables and over-lapped regions is enabled to impose a consensus convergence of the distributed task allocated to each GPU node. We have seamlessly integrated FL-MISR into the computed tomography (CT) imaging system by super-resolving multiple projections of the same view acquired by subpixel detector shift. The SR reconstruction is performed on the fly during the CT acquisition such that no additional computation time is introduced. We evaluated FL-MISR quantitatively and qualitatively on multiple objects including aluminium cylindrical phantoms, QRM bar pattern phantoms, and concrete joints. Experiments show that FL-MISR can effectively improve the spatial resolution of CT systems in modulation transfer function (MTF) and visual perception. Besides, comparing to a multi-core CPU implementation, FL-MISR achieves a more than 50x speedup on an off-the-shelf 4-GPU system.
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